Accordingly, recent studies show that IL-1β contributes to PC pathogenesis by IL-1 receptor-associated kinase 4 (IRAK4)-mediated activation of NFkB and by triggering the JAK2/STAT signaling in TME, particularly in cancer-associated fibroblasts (CAFs) [109,110]. The gene discussed is NFKB1; the disease is pachyonychia congenita.