This patient was diagnosed with a gastrointestinal stromal tumor (GIST) and rectal adenocarcinoma and carried germline P/LP variants in FANCE and RAD51C. Neither of these genes is known to be associated with an increased risk of sarcoma or CRC development, and the relevance of these variants in this case remains unclear. The gene discussed is FANCE; the disease is rectum adenocarcinoma.