In another study, LC09 aptamer was used to specifically target the vascular endothelial growth factor A (VEGFA) of osteosarcoma cancer cells, by functionalizing LC09 aptamer with a PEG-PEI-Cholesterol (PPC) lipopolymer that encapsulated Cas9 and CRISPR/Cas9 plasmids coding for VEGFA gRNA. The gene discussed is VEGFA; the disease is osteosarcoma.