IL1B and Parkinson disease: In this regard, in another PD animal model represented by a 6-OHDA rat model, it was reported that Fluvoxamine treatment attenuated neuronal inflammation, reducing lipid peroxidation, as well as IL-1β, IL-6 and TNFα mRNA levels, while IL-10 and TGF-β levels resulted upregulated in the striatum of treated animals [96].