Other observations revealed characteristic changes in the levels not only of pro-inflammatory cytokines TNF-α and IL-6, but also of the anti-inflammatory cytokine IL-10, both in the spinal cord and in the serum of mice injected intraperitoneally with the IgG from the ALS patients accompanied with subclinical signs of motoneuron diseases, thus, evidencing the importance of the delicate balance between the pro- and anti-inflammatory mechanisms in neurodegeneration such as ALS [61]. Here, IL6 is linked to amyotrophic lateral sclerosis.