Using recombinant WNT5A in melanoma cells expressing low endogenous WNT5A induces a rapid release of exosomes containing the immunomodulatory cytokine interleukin 6 (IL-6) and the pro-angiogenic factors interleukin 8 (IL-8), VEGF and matrix metalloproteinase-2 (MMP2), whereas WNT5A depletion in melanoma cells expressing high endogenous WNT5A causes the reduction of IL-6, IL-8, VEGF and MMP2. The gene discussed is CXCL8; the disease is melanoma.