IL10 and plasma cell myeloma: Other factors that drive T-cell anergy in the myeloma microenvironment are immunosuppressive cell subsets like regulatory T-cells (Tregs) [67,68] and myeloid-derived suppressor cells (MDSCs) [69], or cytokines like interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) [70].