In addition, PKCλ controls signaling by SOX2-hedgehog acyl transferase (HHAT), a master transcriptional regulator of stemness, in lung squamous cell carcinoma [51], and Auranofin, a Par6-PKCλ complex inhibitor, suppresses oncosphere growth from ovarian TICs [52]. This evidence concerns the gene PRKCH and squamous cell lung carcinoma.