HIF1A and diabetes mellitus: In addition, as shown in the Table 3 and Figure 4, the corrected OR also indicated a significant association between HIF1A Pro582Ser polymorphism and reduced risk of diabetes under the allelic (OR = 0.59, 95% CI = 0.46-0.75; P < 0.001), homozygous (OR = 0.16, 95% CI = 0.05-0.54; P = 0.003), recessive (OR = 0.61, 95% CI = 0.47-0.79; P < 0.001) and dominant (OR = 0.18, 95% CI = 0.05-0.58; P = 0.004) genetic models.