CXCL8 and Sepsis: In fact, the effect of LPS+LL-37 inducing CXCL8 in the epithelium differed from immunosuppressive effects of LPS+LL-37 on macrophages and in a sepsis model.2,64,66 In this regard, TNF-α secretion was reduced following LPS+LL-37 treatment of PMA-differentiated human monocytes (THP-1), and CXCL8 synthesis was unaffected.