CXCL1 and infection: In mice, two functional homologs of CXCL8, CXCL1 (keratinocyte chemoattractant (KC)) and CXCL2 (macrophage inflammatory protein-2 (MIP-2)), are regarded as early-phase neutrophil chemokines.28 Of note, mice deficient in CXCL1 have reduced neutrophil recruitment to the colon following infection with C. rodentium.