PLAT and Arterial thrombosis: Plasma tPA protein concentration was increased in obese versus lean mice, but plasma tPA activity was reduced, plasma clot-lysis time was delayed, and time to occlusive carotid arterial thrombosis induced by photochemical injury was shortened in obese mice (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI135919DS1).