In addition, immunofluorescence results (Figure 8D) demonstrated notable reductions in the numbers of cells positive for Ki67, BrdU, Lef1, Gata-3 and AE13, while the cleaved caspase 3 positive cells were potently increased, suggesting repressed HFSC proliferation, migration and keratinocyte differentiation, but increased HF keratinocyte apoptosis in EZH2-/- mice (p < 0.05). Here, CASP3 is linked to hydrops fetalis.