Consequently, cancer systems immunologists have employed targeted amplicon sequencing (typically, of cDNA derived from amplified TCR or BCR mRNA) to evaluate the BCR and TCR repertoires, providing insight into how lymphocytes respond to tumors (Han et al., 2016; Page et al., 2016; Woodsworth et al., 2013; Sims et al., 2016; Linnemann et al., 2013; Jiang et al., 2019; Liu et al., 2018; Chaudhary and Wesemann, 2018; Zhang et al., 2017b). The gene discussed is BCR; the disease is cancer.