CD40 and neoplasm: Furthermore, while FcR binding of tumor-immune complexes has been suggested to promote tumor progression (Andreu et al., 2010), we have found that combining tumor-binding antibodies with DC adjuvants and CD40 agonists results in extremely potent anti-tumor responses in a manner that is FcR-dependent (Spitzer et al., 2017; Carmi et al., 2015; Carmi et al., 2016).