In contrast to infection with ΔospD3, infection with ΔospC1ΔospD3 did not lead to phosphorylation of MLKL or induction of rapid cell death, whereas caspase‐8 activity was elevated in cells infected with ΔospC1 or ΔospC1ΔospD3 (Fig 5A and B). This evidence concerns the gene MLKL and infection.