Further, unbiased epigenetic analyses have provided independent evidence linking BIN1 to AD pathogenesis in several epigenome-wide association studies examining DNA methylation patterns in brain tissue from AD patients, in which BIN1 again emerged as a top hit (De Jager et al., 2014; Chibnik et al., 2015; Yu et al., 2015). The gene discussed is BIN1; the disease is Alzheimer disease.