While another early report suggested increased BIN1 in AD (Chapuis et al., 2013), subsequent reports suggest that variants may reduce BIN1 expression (Glennon et al., 2013; Holler et al., 2014), and the effects may also differ between the neuronal and ubiquitous isoforms (De Rossi et al., 2016). The gene discussed is BIN1; the disease is Alzheimer disease.