MAPT and Alzheimer disease: Tau reduction is protective in many models of AD and it reduces network hyperexcitability in many disease models, including AD and epilepsy models (Chin et al., 2007; Roberson et al., 2007; Holth et al., 2011; Roberson et al., 2011; DeVos et al., 2013; Gheyara et al., 2014; Liu et al., 2017).