BIN1 was first linked to AD in early genome-wide associated studies (GWAS) (Harold et al., 2009; Seshadri et al., 2010) and remains second only to APOE in genome-wide significance in the recent meta-analysis of 94,437 individuals by the International Genomics of Alzheimer’s Disease Project (Kunkle et al., 2019). This evidence concerns the gene APOE and Alzheimer disease.