IL6 and skin aging: 2011). It is also known that various pro-inflammatory factors are increased with UV exposure (Bald et al. 2014). As we discussed above, several pro-inflammatory biomarkers including TNF-α, IL-1, IL-6 could stimulate the production of MMP and therefore causing further degradation of collagen and elastin and accelerating skin aging. Previous studies also confirmed that TNF-α could promote the generation of ROS, which was the major cause of skin aging (Fischer and Maier 2015).