Cell surface membrane structures that fulfill these criteria in most major AML variants and in most (but not all) patients are Siglec‐3 (CD33), Hermes (CD44), CD96, KIT (CD117), the interleukin‐3 receptor alpha‐chain (CD123), AC133 (CD133), FLT3 (CD135), and CXCR4 (CD184) (Table 1).24, 25, 26, 27, 28, 29, 30, 31, 32, 33. Here, PROM1 is linked to acute myeloid leukemia.