Cell surface membrane structures that fulfill these criteria in most major AML variants and in most (but not all) patients are Siglec‐3 (CD33), Hermes (CD44), CD96, KIT (CD117), the interleukin‐3 receptor alpha‐chain (CD123), AC133 (CD133), FLT3 (CD135), and CXCR4 (CD184) (Table 1).24, 25, 26, 27, 28, 29, 30, 31, 32, 33. The gene discussed is CD44; the disease is acute myeloid leukemia.