Carbone et al154 showed serum OPN levels (cut‐off value, 30.53 ng/mL) were the best predictor of poor outcome at day 90 after ischaemic stroke, which is analysed by receiver operating characteristic curve, while Jing et al showed the thrombin‐cleaved OPN levels were significantly correlated with the clinical outcome 12 months after hospital discharge and could discriminate ischaemic stroke patients from healthy individuals at a cut‐off of 166.8 ng/mL.155. The gene discussed is SPP1; the disease is ischemic stroke.