Similarly, by curbing viral replication in the footpad, administration of CpG prior to ECTV infection may protect from lethality but, by drastically reducing virus loads, could result in decreased responses to ECTV in the dLN as we have previously observed in cGAS deficient mice treated with the STING ligand cGAMP (Wong, Montoya, Ferez, Stotesbury, & Sigal, 2019). The gene discussed is CGAS; the disease is infection.