Although high expression of NQO1 has been reported as a poor prognostic factor in hepatoblastoma in a previous study8, the mechanism of high NQO1 expression has not been clarified except for activating mutation of NEF2L2, a transcription factor upstream of NQO1. The current study pointed out the possibility that methylation of NQO1-ARE highly regulated NQO1 expression. Here, NQO1 is linked to hepatoblastoma.