In CL and MCL patients infected with L. braziliensis, an experimental investigation has revealed that production of these cytokines (IFN-γ and TNF-α) and decrease production of regulatory cytokines (IL-10 or the IL-10 receptor) lead to an exaggerated inflammatory response that was responsible for development of immunopathogenesis [25, 97, 98]. This evidence concerns the gene IL10 and mantle cell lymphoma.