It has been confirmed that targeting of the zinc finger E-box binding homeobox 1/2 (ZEB1/2) by miR-192 has been shown to result in renal fibrosis by activation of the TGF-β signaling pathway [65], while Ebadi et al. suggest that enhancing the expression of miR-192 can improve DN and modulate the risk of renal function decline by suppressing fibrogenesis. This evidence concerns the gene ZEB1 and renal fibrosis.