For example, the expression of plaC (acyltransferase), lapA and lapB (aminopeptidases) genes are significantly higher in Legionella during infection of Acanthamoeba castellanii, although neither single plaC (acyltransferase) or double lapA/lapB (aminopeptidases) mutants are impaired for infection (White et al., 2018). The gene discussed is CPQ; the disease is infection.