Variants in genes such as GJA1 (Dasgupta et al., 2001), NKX2.5 (Elliott et al., 2003), NOTCH1 (Garg et al., 2005; McBride et al., 2008; Hrstka et al., 2017; Yang et al., 2017), and MYH6 (Theis et al., 2015; Tomita-Mitchell et al., 2016), as well as observations of syndromic or rare copy number variants (CNVs) in cardiomyogenic genes (Grossfeld, 2007; Grossfeld et al., 2009; Tomita-Mitchell et al., 2012; Warburton et al., 2014; Glidewell et al., 2015) have been associated with HLHS. The gene discussed is MYH6; the disease is hypoplastic left heart syndrome.