The oncogenic roles of AKT1S1 have been reported in colon cancer, liver cancer, lung cancer, prostate cancer, breast cancer, and so on via regulating PI3K/Akt, mTOR, and/or NF-κB signaling pathways (Malla et al., 2015; Lv et al., 2017). Here, AKT1S1 is linked to Familial prostate cancer.