DMD and hyperinsulinemic hypoglycemia, familial, 4: In the present study, we thus focused, for the first time, on evaluating the impact of dystrophin-deficiency on some molecular properties of the excitation-contraction coupling (ECC) and flight-or-fight response in some patient-specific DMD human pluripotent stem cell-derived cardiac cells (DMD-hPSC-CCs) as well as in CRISPR/Cas9 engineered hPSC-CCs (summarized in Graphical abstract).