Interestingly, and although both GNBP3 and PSH-dependent pathway are also required for Toll pathway activation upon Candida glabrata infection, only GNBP3 mutants are susceptible to Candida glabrata infection, implicating that the downstream effector mechanisms like AMP production and melanization activated against different fungal infections may not be the same (Chamilos et al., 2010; Quintin et al., 2013). The gene discussed is TLR4; the disease is fungal infectious disease.