These include (a) the human anti-CTLA-4 mAb ipilimumab for the treatment of metastatic melanoma, (b) the human anti-PD-1 mAbs nivolumab and pembrolizumab for the treatment of melanoma and unresectable/metastatic solid tumors, respectively, and (c) the anti-PD-L1 mAb atezolizumab for patients with metastatic non-small cell lung cancer (127). This evidence concerns the gene CD274 and metastatic melanoma.