The chemoresistance induced by tumor-infiltrating macrophages could also be mediated by the expression of IL-10; therapeutic blockade of IL-10 receptor (IL-10R) had similar effects to CSF-1 neutralization and enhanced tumor response to Paclitaxel and Carboplatin in the MMTV-PyMT transgenic model of luminal B-type mammary carcinoma (54). This evidence concerns the gene IL10RA and neoplasm.