In the present study, we aimed to assess the demographic variables such as age, BMI, monthly income, and periodontal parameters: plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL), and correlate CD163 protein levels and gene expression with the amount of periodontal destruction in subgingival plaque samples of generalized chronic periodontitis patients with and without type II diabetes mellitus. This evidence concerns the gene CD163 and type 2 diabetes mellitus.