MDM2 and neoplasm: After T-cell co-culture, TOV-21G tumor cells were found to have a dead/live tumor cell ratio of 37:1 as compared to tumor cells alone (P = 0.01), whereas high MDM2-expressing tumor cells (OVTOKO and OVMANA) were found to be more resistant to T-cell killing with a much lower ratio of dead/live tumor cells compared to tumor cells alone (4.2:1 and 1.9:1; P = 0.03 and P = 0.07, respectively; Fig. 1b).