The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis by WebGestalt24 (http://www.webgestalt.org) showed that, among these changed TFs, maturity onset diabetes in young pathway was most enriched including HNF4α, HNF1α, FOXA2, and PAX6 (Supplementary Fig. S2a). This evidence concerns the gene HNF4A and type 2 diabetes mellitus.