PAX6 and type 2 diabetes mellitus: The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis by WebGestalt24 (http://www.webgestalt.org) showed that, among these changed TFs, maturity onset diabetes in young pathway was most enriched including HNF4α, HNF1α, FOXA2, and PAX6 (Supplementary Fig. S2a).