Figure 3 shows a heat map depicting differential expression of selected upregulated genes for pNK versus TiNK cells based on calculated Z-scores. KEGG pathway analysis showed that upregulated genes were enriched in pathways related with HIF1, TNF, NFĸB, and transcriptional misregulation in cancer with HIF1 signaling demonstrating the greatest significance (Table 2). The gene discussed is HIF1A; the disease is cancer.