IGF1 and cancer: With normal PNT2 cells, under euglycaemic conditions, EMT was inhibited by IGF-I, whereas opposite effects were observed in the cancer cells, which suggest that with normal epithelial prostate cells, IGF-I prevented a malignant phenotype by maintaining the normal characteristics of differentiated cells whereas in cancer cells, IGF-I promoted a more mesenchymal phenotype that could potentially promote a more aggressive phenotype.