IGF1 and Familial prostate cancer: Figure 2B and 2C show that with 5 mM glucose, IGF-I decreased migration of normal PNT2 cells but promoted migration of the DU145 prostate cancer cells: this reflected the changes observed in the EMT markers upon IGF exposure. However, exposure of PNT2 cells to high glucose alone markedly increased cell migration (p < 0.05) but was still inhibited in the presence of IGF-I (p < 0.05). Similar to PNT2 cells, exposure to high glucose alone increased DU145 cell migration (p < 0.05) but the addition of IGF-I under high glucose conditions could not enhance migration further.