PTGS2 and lung cancer: While we conclude that miR-708 suppression of COX-2/mPGES-1 derived PGE2 has a significant effect on lung cancer cell proliferation, survival, and invasion, the tumor suppressive qualities of miR-708 are most likely a combinatory targeting of multiple oncogenic genes, including survivin, p21, cFLIP, and AKT2 to just name a few [56–62].