CNR2 and myocardial infarction: Using the selective CB2 agonist, JWH-133, and CB2 gene-deficient mice, Defer et al. [23] also revealed that activating the CB2 receptor promoted the survival of cardiac myocytes and protected against I/R-induced myocardial infarction through the direct inhibition of myocyte and fibroblast death and the prevention of myofibroblast activation.