AKT1 and hereditary clear cell renal cell carcinoma: Wei et al. found that treated with Huaier, the expression of the downstream protein p70S6K of mTOR decreased in renal cell cancer cell 786-O, indicating that Huaier has a potential inhibitory effect on renal cell carcinoma through the PI3K/AKT/mTOR/p70S6K pathway [48].