NFKB1 and Nephropathy: Adding Huaier to CP-induced nephropathy, it was found that it can downregulate the PI3K/Akt/mTOR/NF-κB signaling pathway in cisplatin nephrotoxicity cells and downregulate the expression of p-NF-κB. These can never emphasize more that HQH can reduce apoptosis and promote the survival of kidney cell through the NF-κB signaling pathway [8].