NF2 and neoplasm: According to Malouf et al., the Hippo pathway was one of the most frequently altered pathways in sarcomatoid clear-cell renal cell carcinomas (sRCC) and YAP1 knockdown and neurofibromin 2 (NF2) reconstitution suppressed cell proliferation and tumour growth and invasion, both in vitro and in vivo [69].