Our latest study has shown that 4'-O-methybavachalcone significantly reduced cerebral infarction and edema, improved neurobehavioral indexes, inhibited the production of IL-1β, TNF-α, and IL-6 in ischemic brain, and reduced the level of NLRP3, cleaved caspase1, and GSDMD-N (gasdermin D N-terminal domain) in the mouse stroke model and in oxygen glucose deprivation- (OGD-) RAW264.7 cells [42]. This evidence concerns the gene NLRP3 and Stroke.