The NA/STZ-induced T2DM rat model has been used in the present study because of the following lineaments: (a) stable moderate nonfasting hyperglycemia which requires no exogenous insulin to survive; (b) partial loss of β-cells in the islets of Langerhans (-40%); (c) decrease in islets' insulin content by 60%; (d) impaired glucose tolerance; (e) impaired glucose-stimulated insulin secretion; (f) responsiveness to sulfonylurea drugs; and (g) polyphagia and polydipsia [18]. This evidence concerns the gene INS and type 2 diabetes mellitus.