INS and metabolic syndrome: The elevation in blood glucose levels and the inhibition of the insulin synthesis may be referred to (1) a reduced uptake of glucose into peripheral tissues, muscles, and adipose tissues and insulin resistance which may not only induce hyperglycemia but also dyslipidemia [95, 99]; (2) a loss of activity and breakdown of the liver glycogen synthetase-activating system [100]; and (3) a significant decrease in the activities of the glycolytic and lipogenic enzymes, while there was an increase in the activities of gluconeogenic enzymes and hepatic glucose production [101].