In the iBAT, compared with HF group rats, CBPs treatment positively regulated the mRNA expression of peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α), PPARγ and upregulation of uncoupling protein 1 (UCP1) in AM group rats, while simvastatin treatment had no similar effect in SV group rats (Fig. 3f). This evidence concerns the gene UCP1 and hydrops fetalis.