AKT1 and cancer: PI3K/Akt/mTOR signaling pathway is commonly activated and suppression of its activation may inhibit cells proliferation and metastasis in cancers of the lung [10, 11, 50], colorectal [51, 52], esophagus [53], breast [54–56], liver [57, 58], and kidney [59, 60], which has been considered a promising therapeutic target.