However, H-D SLBZ-AP (60 g·kg−1·day−1) tends to show less effect on p-AKT, p-mTOR, p-P70S6, and VEGF protein expression induced by BMLC and the effect of M-D SLBZ-AP is more than that of L-D SLBZ-AP, which may be due to the fact that the expression of p-AKT, p-mTOR, p-P70S6, and VEGF in the marrow from tibia from bone metastasis with small-cell lung cancer (BMLC) mice was measured and cells in the marrow from tibia might include cancer cells and normal cells. The gene discussed is AKT1; the disease is cancer.