SOD1 and obesity due to melanocortin 4 receptor deficiency: The present study outcomes are comparable with the results of [15], who proved that the grape's skin plays an essential role, exerting great in vivo or in vitro antioxidative effects, by improving the oxidative stress markers, like SOD, catalase, and GSH-Px, in addition to the TAC's levels growing, in the obese rats serum and, consequently, overcoming the obesity-induced oxidative stress damage [15].