BRCA1 and cancer: Although male breast cancer is a rare disease in the general population, with a lifetime risk of 0.1% accounting for less than 1% of all cancers in men and about 1% of all breast cancers, the cumulative incidence is significantly increased in male BRCA1/2 carriers and is estimated at 1% in BRCA1 carriers and 7-8% in BRCA2 carriers [12, 13, 30].