The clinical guidelines in HBOC of the hereditary cancer working group from SEOM point towards the controversial results on the association of BRCA1/2-mutations and colorectal cancer and towards the possible differences between BRCA1 and BRCA2, but latest version of these guidelines does not mention colorectal cancer surveillance, while specific recommendations for BRCA1 were reported in the previous version [42, 51]. This evidence concerns the gene BRCA2 and colorectal cancer.