For cold tolerance, Frost (Fst) is commonly upregulated in response to cold acclimation and during recovery from cold stress (Goto, 2001; Qin et al., 2005; Sinclair et al., 2007; Colinet et al., 2010), and it is also located within a QTL for chill coma recovery time (Morgan and Mackay, 2006). The gene discussed is FST; the disease is type 2 diabetes mellitus.