Notably, most genes were associated with neurotrophin signaling, oocyte meiosis, biocarta chrebp2, renal cell carcinoma and the mitogen activated kinase-like protein (MAPK) signaling pathway followed by the biocarta insulin, biocarta insulin like growth factor 1 receptor (IGF1R), gap junction, insulin signaling and progesterone mediated oocyte maturation pathways. The gene discussed is BDNF; the disease is renal cell carcinoma.