Notably, most genes were associated with neurotrophin signaling, oocyte meiosis, biocarta chrebp2, renal cell carcinoma and the mitogen activated kinase-like protein (MAPK) signaling pathway followed by the biocarta insulin, biocarta insulin like growth factor 1 receptor (IGF1R), gap junction, insulin signaling and progesterone mediated oocyte maturation pathways. This evidence concerns the gene BDNF and hereditary clear cell renal cell carcinoma.