While several drugs targeting the ACE2-dependet entry pathway for SARS-CoV-2 still await for validation and assessment of their side effects (6, 7, 49, 59), at least three clinical trials aimed to elucidate the protective role of vitamin D role on COVID-19 disease severity are currently progressing in Spain, France and United States (60–62). The gene discussed is ACE2; the disease is COVID-19.