IFNB1 and myeloid sarcoma: While type II IFN, i.e., IFN-γ, whose expression is dramatically increased in MS, is linked to activation and maintaining of inflammation, type I IFNs (mainly IFN-αs and IFN-β) are abundantly secreted in response to viral infection, acting early during the immune response to potentiate antiviral responses and to prime and maintain adaptive immunity (7).