IL6 and rheumatoid arthritis: In the 2019 update of the European League Against Rheumatism (EULAR) recommendations for the management of RA, the use of a biological agent (including tocilizumab and sarilumab) is encouraged as second-line therapy in the presence of poor prognostic factors, and IL-6 inhibitors should be preferred over the other biological agents in patients who cannot use concomitant conventional treatment (30).