Although the frequencies of these myeloid cells in the spleens were similar between WT-IMQ and Padi4 KO-IMQ mice, the numbers of CD11b+CD11c+ cells and monocytes (CD11b+Ly6Chigh) decreased in the spleen of Padi4 KO-IMQ mice (Figures 3A–C), which may partially explain the improvement of splenomegaly in Padi4 KO-IMQ mice shown in Figure 1A. The gene discussed is PADI4; the disease is Splenomegaly.