They inhibit the immune response at different levels like B, CD4 Th1, CD8 T cell, and NK cell activation or dendritic cell maturation and it has been found that sepsis patients present reduced numbers of CD4 Th1, CD8 T cell, and NK cell (108) and increased Treg cell number and activity (109–111), which contributes to secondary infection. Here, CD8A is linked to Sepsis.