It has been shown that extracellular GzmA is able to induce the production of different inflammatory cytokines such as IL-1β, TNF-α IL-6, or IL-8 in both mouse and human cells like monocytes, macrophages, fibroblasts, endothelial and epithelial cells (17, 20) (Table 1) which might contribute to the cytokine storm observed during sepsis. This evidence concerns the gene IL1B and Sepsis.