While in several crFMF cases IFN-α seemed to induce a marked decrease in both severity and frequency of the attacks, alone or in combination with colchicine (69–72), a double-blind randomized clinical trial of 22 FMF patients comparing IFN-α with placebo (without concomitant colchicine) did not demonstrate clear efficacy of IFN-α in reducing severity of attacks or inflammatory markers (73). Here, IFNA1 is linked to familial Mediterranean fever.