Downregulation of fatty acid β-oxidation pathways as well as TAG hydrolase, including PPAR-α, carnitine palmitoyltransferase 1 (CPT1), acyl-CoA oxidase (ACO), and L-FABP, has been strongly linked to glomerular hyperfiltration and inflammation as evidenced by studies of biopsies from DM patients (7). The gene discussed is DDHD2; the disease is diabetes mellitus.